Comprehensive and in-depth in its coverage, Atherosclerosis: Cellular, Molecular & Biochemical Mechanism and Novel Therapy reviews the recent progress in atherosclerosis research and offers cutting edge perspectives from experts in the field.

Contributors ix ForewordJoseph Loscalzo xv PrefaceEric N. Olson xvii Section I: Risk Factors: Old and New 1 1 Lipoproteins 3Ming-Lin Liu and Daniel J. Rader 2 Role of Dysglycemia in Atherosclerosis 15David R. Clemmons 3 Glycation, Inflammation and RAGE: Mechanisms Contributing to the Accelerated Atherosclerosis of Diabetes 27Ravichandran Ramasamy, Shi Fang Yan, and Ann Marie Schmidt 4 Inflammation 43Caitlin Collins, Ellie Tzima, and Cam Patterson 5 Homocysteine: A Controversial Cardiovascular Risk Factor 53Sanjana Dayal and Steven R. Lentz 6 Hypertension as a Risk Factor for Atherosclerosis 63Annet Kirabo and David G. Harrison 7 The Genetics of Atherosclerosis: From Polymorphisms to Populations 77Paul Johnson, Jack Kuritzky, and Marschall Runge 8 Life Style 93Wayne E. Cascio Section II: Cellular Mechanisms 105 9 Endothelial Cells 107G. Brandon Atkins, Gabriela Orasanu, and Mukesh K. Jain 10 Vascular Smooth Muscle Cells 117Dario F. Riascos-Bernal and Nicholas E. S. Sibinga 11 Fibroblasts 129Christopher Mack 12 Monocytes and Macrophages in Atherosclerosis 141Shu Meng, Pu Fang, Xiaofeng Yang, and Hong Wang 13 Lymphocytes and Atherosclerosis 155Anthony Virtue, Jietang Mai, Hong Wang, and Xiaofeng Yang 14 Stem Cells 173Arjun Deb 15 Platelets 187Jerry Ware and Adam Corken 16 Development and Use of Mouse Models of Atherosclerosis 197Peggy Robinet and Jonathan D. Smith Section III: Molecular Mechanisms 207 17 Mechanisms of the Renin Angiotensin System Influencing Atherosclerosis 209Hong Lu and Alan Daugherty 18 The Role of Caveolae and Caveolins in Atherogenesis 221Victor Rizzo 19 Lysosomal Molecular Derangements in Atherosclerosis 235Pin-Lan Li and Yang Zhang 20 C-Reactive Protein and Its Pathophysiological Roles in Atherosclerosis 247Jianglin Fan, Jifeng Zhang, and Yuqing Eugene Chen 21 Paraoxonases 257Srinivasa T. Reddy 22 Prostanoids, Their Receptors, and Atherogenesis 267Domenico Praticò 23 Extracellular Phospholipases: Role in Inflammation and Atherosclerotic Cardiovascular Disease 279Uwe J.F. Tietge 24 Apolipoprotein-B: The Crucial Protein of Atherogenic Lipoproteins 291Kevin Jon Williams and Edward A. Fisher 25 HDL Receptor Scavenger Receptor BI: A Multipurpose Player in Cholesterol and Steroid Metabolism in Mice and Man 313Ying Zhao, Menno Hoekstra, Suzanne J. A. Korporaal, Theo J. C. Van Berkel, and Miranda Van Eck 26 Pro and Anti-Inflammatory Cytokine Networks in Atherosclerosis 329Michael V. Autieri 27 E CM and Atherosclerosis 343Jie Du, Ying Wang, and Lixin Jia Section IV: Biochemical Mechanisms 353 28 Effects of Nitric Oxide on Atherosclerosis 355Terrence Pong and Paul L. Huang 29 Protective Role of Heme Oxygenase-1 in Atherosclerosis 365William Durante 30 Roles of Reactive Oxygen Species in Physiology and Pathology 379Ping Song and Ming-Hui Zou 31 Hydrogen Sulfide: Role in Atherosclerosis, Mechanisms, and Therapeutic Potential 393Elvis A. Peter, Jai Varma, and Christopher G. Kevil 32 Methylation and Atherosclerosis 405Xin-Yu Xiong, Shu Meng, Xiaofeng Yang, and Hong Wang 33 Micromanaging Atherogenesis: Role of Micrornas in Atherosclerosis 423Shusheng Wang and Chastain Anderson 34 Posttranslational Modifications: Role in Atherosclerosis 437Justyna Fert-Bober, Ronald J. Holewinski, Joel A. Kooren, and Jennifer E. Van Eyk 35 Phosphorylation Regulation by Kinases and Phosphatases in Atherosclerosis 453Katherine J. Elliott and Satoru Eguchi 36 Effect of MMPs on Cardiovasculature and Blood Flow: Role of Ros, Mitophagy, and Antioxidants 467Thomas P. Vacek, Diana Neamtu, and Suresh C. Tyagi Section V: Clinical Management 479 37 Impact of Preventive Therapies on Clinical Management and Outcomes 481Danny Eapen, Ahsan Achtchi, Reynaria Nieva, Kiran Valiani, Faresa Zarreen, Aalok Patel, Allen Dollar, Ijeoma Isiadinso, Susmita Parashar, Jefferson Baer, Kreton Mavromatis, and Laurence Sperling 38 Risk Stratification in Clinical Practice 495Phil Mendys, Golsa Joodi, and Ross J. Simpson, Jr. 39 Molecular Imaging 503Arun K. Thukkani and Farouc A. Jaffer 40 Pharmacological Therapy in the Management of Acute Coronary Syndromes 517Andrew J. Sampson, Timir Paul, and George A. Stouffer 41 Targeted Molecular Therapeutics for Atherosclerosis 533Lantz C. Mackey and Jonathon W. Homeister 42 High-Density Lipoprotein Therapies—Then and Now 545Henry J. Pownall, Corina Rosales, Baiba K. Gillard, and Antonio M. Gotto, Jr. 43 Stem Cell Therapeutics 557Mei Mei Wong and Qingbo Xu 44 Advances in Surgical Revascularization 567Stephen J. Forest, Ahmed Khan, and Joseph J. DeRose, Jr. Index 579