The two-volume set LNCS 14975 + 14976 constitutes the proceedings of the First International Conference on Artificial Intelligence in Healthcare, AIiH 2024, which took place in Swansea, UK, in September 2024. The 47 full papers included in the proceedings were carefully reviewed and selected from 70 submissions. They were organized in the following topical sections: Part I: Personalised Healthcare and Medicine; AI driven early diagnosis and prevention; AI driven robotics for healthcare; AI in mental health;  Part II: AI in proactive care and intervention; AI-aided medical imaging and analysis; Medical signal and image processing; Assisted living technology; Digital twinning, virtual pathology and oncology; Patient data, privacy and ethics.