In this issue of Interventional Cardiology Clinics, guest editor Dr. Luis Ortega Paz brings his considerable expertise to the topic of Antiplatelet and Anticoagulation Therapy in Cardiovascular and Pulmonary Embolism Transcatheter Interventions. Top experts in the field discuss regulation of platelet activation and coagulation; genetic determinants of P2Y12 inhibitors and clinical implications; switching P2Y12 receptor inhibiting therapies; high bleeding risk in patients undergoing coronary and structural heart interventions; and much more. Contains 13 relevant, practice-oriented topics including antithrombotic therapy in atrial fibrillation patients undergoing coronary stenting; antithrombotic therapy in patients undergoing transcatheter aortic valve replacement; antithrombotic therapy in patients undergoing peripheral artery interventions; antiplatelet therapy in women; and more. Provides in-depth clinical reviews on antiplatelet and anticoagulation therapy in cardiovascular and pulmonary embolism transcatheter interventions, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.