Cardiac Drug Development Guide outlines, in detail, the therapeutics of cardiac medicine currently at the cutting edge of scientific research and development around the world. Cardiac Drug Development Guide has many distinctive and outstanding features that set it apart from other cardiac pharmacology books.

Cardiac Drug Development.- Novel Molecular Targets for Cardiac Drug Development.- The Role of Cardiac Pacemaker Currents in Antiarrhythmic Drug Discovery.- Oxygen Free Radicals in Heart Disease.- Mitogen-Activated Protein Kinases-Mediated Signaling in Cardiac Pathology.- Development of Anti-Inflammatory Drugs for Cardiovascular Disease.- Development and Use of Platelet Glycoprotein Antagonists in Heart Disease.- The Sodium-Hydrogen Exchange System in the Heart.- Nitric Oxide and Cardiac Ischemia.- Functional Endpoints Evaluating Cardiac Drug Activity.- Ionic Mechanisms of Atrial Fibrillation.- Targeting Ischemic Ventricular Arrhythmias.- Biochemical Mediators of Ventricular Arrhythmias in Ischemic Heart Disease.- Heterologous Expression Systems and Screening Technologies in Ion Channel Drug Discovery.- Molecular Diversity of Ion Channels in the Mouse Heart.- Delayed Protection of the Myocardium.- Clinical Aspects in Cardiac Drug Development.- Cardiac Troponin Testing for Detection of Myocardial Infarction.- A Genetic Basis for Cardiac Arrhythmias.- Myocardial Adenoviral Vector Delivery for Cardiovascular Gene Therapy.- The Role of Pharmacometrics in Cardiovascular Drug Development.- Gender Differences in Heart Failure.- Angiogenesis Therapies for Coronary Artery Disease.

The revolution in molecular medicine makes it imperative to integrate the classical and molecular approaches to drug development for the treatment of heart disease, the number one killer in North America and Europe. In the Cardiac Drug Development Guide, basic medical researchers, clinicians, and pharmacologists join forces to comprehensively survey the most recent breakthroughs in molecular cardiology and review the latest drug discoveries in cardiac and cardiovascular medicine. Topics range from novel molecular targets for cardiac drug development, to functional endpoints for evaluating cardiac drug activity, to clinical aspects of cardiovascular therapeutics. The authors describe the most advanced procedures in cardiovascular pharmacology, including in vivo and in vitro whole animal studies, the electrophysiological methods used to study pacemaker cells, and the application of biochemical principles and technologies to novel therapeutic agents. Also discussed are the methods used to express the ion channels involved in cardiovascular pharmacology, adenoviral vector delivery for cardiovascular gene therapy, pharmacometrics in cardiovascular drug development, gender differences in heart failure, and angiogenesis therapies for coronary heart disease. Each chapter concisely illustrates the concepts described and includes comprehensive background information, detailed figures and tables, and an up-to-date list of the most important references. Comprehensive and easy-to-understand, the Cardiac Drug Development Guide offers pharmacologists, cardiologists, and physiologists not only a gold-standard survey of the many different methods being used to develop new heart drugs, but also details powerful new ways in which cardiovascular disease is targeted, from the whole organ to the genetic level.

"This book provides a comprehensive overview of many advanced procedures in cardiac pharmacology that should be useful for graduate students and academic scientists as well as researchers in the pharmaceutical and biotechnology drug industries. This is an excellent book for researchers with an interest in cardiac pharmacology. Chapters address a broad spectrum of therapeutic areas and discuss appropriate molecular, biochemical, and electrophysiological in vitro as well as in vivo approaches used in the investigation of cardiovascular pharmacology. Moreover, the book addresses current clinical therapeutic trends in cardiovascular medicine."-Doody's Health Sciences Book Review Journal "The scope of material covered is comprehensive, providing eclectic coverage of some very topical issues in cardiac biology and cardiac medicine...most of the chapters will be of interest to a much wider audience than pharmacologists...a worthwhile purchase." - Journal of Pharmacological and Toxicological Methods "This textbook is a comprehensive look into the latest in cardiovascular drug developments and novel therapeutic agents. It covers a broad spectrum of therapeutic areas including ionic channels, adenoviral vector delivery for cardiovascular gene therapy, pharmacometrics, and gender differences in heart failure and angiogenesis therapy in coronary heart disease. It would be useful for clinical researchers and pharmacologists in cardiac drug development. Research scientists, graduate students and pharmacologists involved in both the pharmaceutical and biotechnological drug industries would benefit from this book." - E-STREAMS