This book troubles the ways young people have been constructed as ‘trouble’ through critical readings of the effects and impacts, politically and ideologically, globally and locally, of scholarship and practice directed at South African young people’s sexualities over the last three decades of addressing HIV, GBV and other sexual and gender justice challenges.Located primarily in South Africa, the book speaks to global concerns about the politics of knowledge and transnational flows of information and practice with respect to gender and sexuality and is framed by global imperatives and analyses located in transnational, postcolonial and intersectional feminist frameworks. The key argument developed here, and explored in relation to several different forms of research and practice, is that efforts to challenge HIV, GBV and unequal sexual and gender practices among young people, particularly as evident in heterosexual relationships, have tended to reflect and reproduce (re)new(ed) orthodoxies about sexuality, gender, family and young people, while bolstering global and local racist, classist ‘othering’ of certain communities and nation-states, and reiterating the ‘innocence’ and authority of those already privileged and centred.The book contributes to critical reflexive work on global practices of knowledge and its complex enmeshment with power in the terrain of sexual and gender justice work aimed at young people.