Following the metaphor of "the world upside-down," this essay collection highlights the importance of the humanities in addressing, along with the sciences, pressing challenges in today's rapidly changing world. Crossing across a variety of disciplines, historical periods, and regions in the world, this volume represents a useful tool for humanities scholars and students exploring the key role of our disciplines in public debates about pressing issues, such as the refugee crisis, climate change denialism, environmental justice, racism, and the current worldwide crisis of democracy. It provides practical examples of how societies throughout the world have historically coped with unexpected and distressing changes in government, core values, axiomatic systems, assumptions, beliefs, ideology, or cultural constructions. The feeling of topsy-turvy consternation as a result of sudden, harrowing change, as is shown here, is not new; rather, it has simply evolved throughout time and space.