PART I MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY 1. Anatomy and Physiology of the Gene 2. Epigenomics in Hematology 3. Genomic Approaches to Hematology 4. Regulation of Gene Expression in Hematology 5. Genome Editing 6. Signaling Transduction and Metabolomics 7. Protein Architecture: Relationship of Form and Function 8. Pharmacogenomics and Hematologic Diseases PART II CELLULAR BASIS OF HEMATOLOGY 9. Hematopoietic Stem Cell Biology 10. Mitochondria and Hematopoiesis 11. Cytokines, Chemokines, Other Growth Factors, and Their Receptors 12. Role of Chemokines in Leukocyte Trafficking 13. Stem Cell Model of Hematologic Diseases 14. Hematopoietic Microenvironment 15. Cell Adhesion 16. Current Biology of Stem Cell Homing and Mobilization: Dynamic Interactions Between Hematopoietic Stem and Progenitor Cells and Their Surrounding Bone Marrow Microenvironment 17. Control of Cell Division 18. Cell Death 19. Aging and Hematopoiesis PART III IMMUNOLOGIC BASIS OF HEMATOLOGY 20. Dendritic Cell Biology 21. Natural Killer Cell Immunity and Therapy 22. B-Cell Development 23. Complement and Immunoglobulin Biology Leading to Clinical Translation 24. T-Cell Immunity 25. Unmodified Ex Vivo Expanded T Cells 26. Treatment of Hematologic Malignancies with Genetically Modified T Cells PART IV DISORDERS OF HEMATOPOIETIC CELL DEVELOPMENT 27. Biology of Erythropoiesis, Erythroid Differentiation, and Maturation 28. Granulocytopoiesis and Monocytopoiesis 29. Thrombocytopoiesis 30. Inherited Bone Marrow Failure Syndromes 31. Aplastic Anemia 32. Paroxysmal Nocturnal Hemoglobinuria 33. Acquired Disorders of Red Cell, White Cell, and Platelet Production PART V RED BLOOD CELLS 34. Pathobiology of the Human Erythrocyte and Its Hemoglobins 35. Approach to Anemia in the Adult and Child 36. Iron Homeostasis and Its Disorders 37. Disorders of Iron Homeostasis: Iron Deficiency and Overload 38. Anemia of Chronic Inflammation 39. Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias 40. Megaloblastic Anemias 41. Thalassemia Syndromes 42. Pathobiology of Sickle Cell Disease 43. Clinical Aspects of Sickle Cell Disease 44. Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias 45. Red Blood Cell Enzymopathies 46. Red Blood Cell Membrane Disorders 47. Autoimmune Hemolytic Anemia 48. Extrinsic Nonimmune Hemolytic Anemias PART VI NON-MALIGNANT LEUKOCYTES 49. Neutrophilic Leukocytosis, Neutropenia, Monocytosis, and Monocytopenia 50. Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia 51. Disorders of Phagocyte Function 52. Congenital Disorders of Lymphocyte Function 53. Pediatric and Adult Histiocytic Disorders 54. Lysosomal Storage Diseases, Focusing on Gaucher Disease: Perspectives and Principles 55. Epstein-Barr Virus and Associated Lymphoproliferative Conditions PART VII HEMATOLOGIC MALIGNANCIES 56. Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications 57. Conventional and Molecular Cytogenomic Basis of Hematologic Malignancies 58. Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies 59. Pathobiology of Acute Myeloid Leukemia 60. Clinical Manifestations and Treatment of Acute Myeloid Leukemia 61. Myelodysplastic Syndromes 62. Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults 63. Acute Myeloid Leukemia in Children 64. Blastic Plasmacytoid Dendritic Cell Neoplasm 65. Myelodysplastic Syndromes and Myeloproliferative Neoplasms in Children 66. Pathobiology of Acute Lymphoblastic Leukemia 67. Clinical Manifestations and Treatment of Childhood Acute Lymphoblastic Leukemia 68. Acute Lymphoblastic Leukemia in Adults 69. Chronic Myeloid Leukemia 70. The Polycythemias 71. Essential Thrombocythemia 72. Primary Myelofibrosis and Chronic Neutrophilic Leukemia 73. Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes 74. Eosinophilia, Eosinophilic Neoplasms, and the Hypereosinophilic Syndromes 75. Mast Cells and Mastocytosis 76. Chronic Lymphocytic Leukemia 77. Hairy Cell Leukemia 78. The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas 79. Origin of Hodgkin Lymphoma and Therapeutic Targets 80. Hodgkin Lymphoma 81. Origin of Non-Hodgkin Lymphoma and Therapeutic Targets 82. Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma 83. Marginal Zone Lymphomas (Extranodal/MALT, Splenic, and Nodal) 84. Diffuse Large B-Cell Lymphoma of the Central Nervous System 85. High-Grade B-Cell Lymphomas 86. Mantle Cell Lymphoma 87. Virus-Associated Lymphoma 88. Malignant Lymphomas in Childhood 89. T-Cell Lymphomas 90. Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma 91. Multiple Myeloma 92. Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma 93. Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis) PART VIII COMPREHENSIVE CARE OF PATIENTS WITH HEMATOLOGIC MALIGNANCIES 94. Key Considerations for Managing Infections in the Compromised Host 95. Principles of Radiation Therapy for Hematologic Disease 96. Grading and Toxicity Management after Immune Effector Therapy 97. Identification and Management of Checkpoint Inhibition Toxicity 98. Psychosocial Aspects of Hematologic Disorders 99. Pain Management and Antiemetic Therapy in Hematologic Disorders 100. Palliative Care 101. Therapy-related Late Effects of Hematologic Malignancies PART IX TRANSPLANTATION AND OTHER CELL-BASED THERAPIES 102. Practical Aspects of Hematopoietic Stem Cell Harvesting and Mobilization 103. Graft Engineering and Cell Processing 104. Principles of Cell-Based Genetic Therapies 105. Indications, Outcomes, and Donor Selection for Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults 106. Unrelated Donor Hematopoietic Cell Transplantation 107. Haploidentical Hematopoietic Stem Cell Transplantation 108. Cord Blood Transplantation 109. Graft-versus-Host Disease and Graft-versus- Leukemia Responses 110. Supportive Care for the Transplant Patient PART X TRANSFUSION MEDICINE 111. Human Blood Group Antigens and Antibodies 112. Principles of Red Blood Cell Transfusion 113. Clinical Considerations in Platelet Transfusion Therapy 114. Human Leukocyte Antigen and Human Neutrophil Antigen Systems 115. Principles of Plasma and Plasma Derivatives 116. Hemapheresis 117. Transfusion Reactions to Blood and Hematopoietic Stem Cell Therapy Products 118. Transfusion-Transmitted Diseases 119. Pediatric Transfusion Medicine 120. Transfusion and Apheresis Support for Sickle Cell Disease Patients PART XI HEMOSTASIS AND THROMBOSIS 121. Overview of Hemostasis and Thrombosis 122. Blood Vessels 123. Megakaryocyte and Platelet Structure 124. Molecular Basis of Platelet Function 125. Molecular Basis of Blood Coagulation 126. Evaluation of the Patient with Suspected Bleeding Disorders 127. Laboratory Evaluation of Hemostatic and Thrombotic Disorders 128. Acquired Disorders of Platelet Function 129. Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura 130. Thrombocytopenia Caused by Hypersplenism, Platelet Destruction, or Surgery/Hemodilution 131. Heparin-Induced Thrombocytopenia 132. Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes 133. Structure, Biology, and Genetics of von Willebrand Factor 134. Hemophilia A and B 135. Rare Coagulation Factor Deficiencies 136. Transfusion Therapy for Coagulation Factor Deficiencies 137. Disseminated Intravascular Coagulation 138. Hypercoagulable States 139. Antiphospholipid Syndrome 140. Venous Thromboembolism 141. Prevention and Treatment of Venous Thromboembolism in Pregnancy 142. Atherothrombosis 143. Antithrombotic Drugs 144. Stroke 145. Acute Coronary Syndromes 146. Peripheral Artery Disease 147. Atrial Fibrillation 148. Bleeding and Clotting Disorders in Pediatrics PART XII CONSULTATIVE HEMATOLOGY 149. Hematologic Changes in Pregnancy 150. Hematologic Manifestations of End-Organ Failure 151. Hematologic Manifestations of Solid Tumors 152. Hematologic Manifestations of HIV/AIDS 153. Hematologic Findings and Consequences of Novel Coronavirus (SARS-CoV-2) Infection 154. Hematologic Aspects of Parasitic Diseases 155. Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis 156. The Spleen and Its Disorders 157. Aging and Hematologic Disorders 158. Onco-cardiology: Focus on Cardiac Complications of Hematologic Treatments 159. Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations 2408.e1 Chapter 159 can be found online at Elsevier eBooks for Practicing Clinicians Index